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MORE women with breast cancer could be spared chemotherapy if doctors switched to a new genetic test, research shows.
“EPclin (EndoPredict) Markedly Outperformed RS (Oncotype DX®) Across the 10-Year Follow-up Period” in a Large Head-to-Head Breast Cancer Study
Feb 11, 2016 | a GenomeWeb staff reporter
NEW YORK (GenomeWeb) – More young women with breast cancer are undergoing BRCA1 and BRCA2 mutation testing, according to a Dana-Farber Cancer Institute-led team of researchers.
Cancer is a disease of abnormal gene function. Some gene changes that lead to cancer may be inherited. Breast, ovarian, prostate, and colon are some of these cancers that are linked to a family history. The genetic mutations that cause many of the known hereditary cancer syndromes have been identified, and genetic testing can confirm whether a condition is the result of an inherited syndrome. Genetic profiling may help you or other family members in planning health care for the future.
The majority of cardiovascular disease (CVD) is caused by risk factors that can be controlled, treated or modified. However, there are some major CVD risk factors that cannot be controlled. Current risk functions evaluate characteristics which can only be identified once they appear, without considering other potential factors such as the patient’s genetic constitution. Genetic profiling may provide personalized information, enabling cardiovascular risk to be identified in a more precise manner.
Getting your child’s illness diagnosed might feel like a never-ending quest—especially if he or she is suffering from a complicated neurological or metabolic disorder such as mitochondrial disorder, epilepsy and seizure, or neuro- developmental disorder. Multiple lines of evidence support that genetic factors play a pivotal role in the etiology of these disorders. Your child’s unique genetic profile may help shed light on new information that could lead to a more accurate diagnosis and potential treatment options.
Rare genetic disorders can go undiagnosed for years. The lack of a diagnosis can have considerable adverse effects for patients and their families, including failure to identify potential treatments, failure to recognize risk of recurrence in subsequent pregnancies, and failure to provide anticipatory guidance and prognosis. Genetic testing has proven to be effective in detecting rare variants in an individual’s genome, offering hope to individuals with previously undiagnosed or untreated rare disorders.