Hereditary Breast and Ovarian Cancer (HBOC) Syndrome

HBOC syndrome is an inherited condition that increases your risk for ovarian, breast, pancreatic and prostate cancer. The vast majority of HBOC is due to an alteration or mutation in either the BRCA1 or BRCA2 genes. These gene mutations can be inherited from either your mother or father.

Am I at risk for hereditary cancer?

This quiz can help you get the information you need to discuss your risk of cancer with your doctor and ask for further evaluation. If you take the quiz and find red flags in your own history or your family history, you may benefit from hereditary cancer testing. This quiz covers the following hereditary cancers:

  • Breast Cancer
  • Ovarian Cancer
  • Colon Cancer
  • Uterine Cancer
  • Pancreatic Cancer

To begin the process of seeing if genetic testing is right for you, check out Myriad’s Hereditary Cancer Quiz:

What is BRACAnalysis®?

BRACAnalysis® is a test developed by Myriad Genetic Laboratories that measures a woman’s risk of developing hereditary breast or ovarian cancer. It detects mutations in the BRCA1 and BRCA2 genes, which are responsible for the vast majority of hereditary breast and ovarian cancers. Only a small blood sample is taken for analysis.

BRACAnalysis® is recommended for individuals at risk for hereditary breast or ovarian cancer.

How will BRACAnalysis® testing benefit me?

Knowing if you have a BRCA gene mutation can help you calculate your risk and inform your family of their potential risk of hereditary cancer. The BRACAnalysis® test results will enable you to make informed choices and take proactive steps to be ready against hereditary cancer. They may also help your doctor to manage your healthcare needs more effectively.

Why choose Myriad?

Over the last 20 years, Myriad has delivered more than one million test results. Results are reviewed rigorously in a strict quality control process, with a second round of testing for reportable mutations. Myriad has the lowest Variant of Uncertain Significance (VUS) rate globally with a <3% VUS rate (0.6% for BRCA1 mutations). A lower VUS rate means a lower chance of resulting in an uncertain result, which means more confidence and clarity in your results.

HBOC and BRACAnalysis® FAQs

[accordion][accordion-item title=”I already know I have a family history of cancer. Why should I get tested?”]Testing for a hereditary cancer risk helps you and your healthcare professional understand your risk so you can make the best choices for preventive care. Knowing your family history is an important first step, but testing can give you a more accurate picture of your risk. [/accordion-item][accordion-item title=”I already have cancer. Why should I get tested?”]Testing for a hereditary cancer helps you and your healthcare professional understand your risk for developing a second primary cancer. This information can allow you to make the best choices for preventive care. [/accordion-item][accordion-item title=”Is testing recommended for everyone?”]While testing is the most accurate way to determine the risk of hereditary cancer, only people who have cancer in their family or a personal history of the disease need to be tested. If you have had cancer and/or cancer runs in your family, let your healthcare professional know. To help you assess whether you may benefit from hereditary cancer genetic testing, take the Myriad Hereditary Cancer Quiz. This simple, 30-second quiz can help you get the information you need to discuss your risk of cancer with your healthcare professional and ask for further evaluation.[/accordion-item][accordion-item title=”How do I get tested?”]Speak to your doctor. Once your doctor orders a test for you from us, we will take care of the rest. The clinic will take a small blood sample and send it to the lab for testing. The lab cannot accept a test directly from you, as a doctor first needs to assess whether or not the test is right for you. Once the testing is completed, a report will be sent to your doctor who will then go through and explain your results to you, and suggest the next steps. [/accordion-item][accordion-item title=”Can I use any other sample collection kit that is not provided by Myriad?”]No! Our processes have been optimized and validated with the kits we provide. [/accordion-item][accordion-item title=”Which completed forms must accompany my sample?”]The clinic will help you complete and sign an Informed Consent Form. This form will be submitted with the sample. The consent form will be used to match your sample to the test request submitted by the doctor, and is needed to let the lab know that you have agreed to send your sample for the test. Samples received without these forms cannot be processed, as your consent is required to test your sample.[/accordion-item][accordion-item title=”Who will receive the test results?”]Myriad will provide your test report to the healthcare professional who ordered the test. [/accordion-item][accordion-item title=”Why are the results of testing sent directly to the ordering healthcare professional rather than the patient or parent of a patient?”]Results are sent to the ordering healthcare professional as they would need to discuss the results, result interpretation, treatment management, and any follow-up testing with you.[/accordion-item][/accordion]