by Myriad Genetics, Inc.
Lynch Syndrome (HNPCC), MAP
Lynch syndrome, also known as hereditary nonpolyposis colorectal cancer (HNPCC), is an inherited condition that causes an increased risk for colorectal cancer, gynecological cancers, as well as other related cancers. The majority of Lynch syndrome is due to mutations in the MLH1, MSH2, MSH6, PMS2, or EPCAM (also known as TACSTD1) or MYH genes. These mutations can be inherited from either your mother or father.
People with Lynch syndrome are at higher risk of developing several different types of cancer, including:
- Colorectal cancer
- Uterine (endometrial) cancer
- Ovarian cancer
- Stomach cancer
- In addition, rarely, urinary/renal, pelvic, biliary tract, small bowel, pancreatic, and brain cancers
Some people with Lynch syndrome may also develop sebaceous adenomas, which are noncancerous tumours of an oil-producing gland in the skin.
MYH-associated polyposis (MAP) is a hereditary condition that causes an increased risk for colorectal cancer and colorectal polyps. Individuals with MAP often do not have a family history of colon cancer or colon polyps in family members (although siblings may be affected). MAP is caused by mutations in the MYH gene, and individuals with MAP have mutations in both of their MYH genes (one from each parent).
Am I at risk for Lynch Syndrome / MAP?
Knowing your risk for Lynch syndrome can help you and your healthcare professional make better, more informed decisions about your health, before the onset of cancer or before a second cancer has had a chance to develop. Genetic testing for hereditary colon cancer should be considered if:
- Have had colorectal or uterine cancer before age 50
- Have had an abnormal MSI/IHC tumour test result (colorectal/uterine)
- Have had two or more Lynch syndrome cancers at any age
- Have had a Lynch syndrome cancer and one or more of your relatives has also had a Lynch syndrome cancer
- Have a previously identified Lynch syndrome mutation in the family
- Has had two or more family members with a Lynch syndrome cancer, one before the age of 50
- Has had three or more family members with a Lynch syndrome cancer at any age
- Has a previously identified Lynch syndrome mutation in the family
What is COLARIS® testing?
COLARIS® testing does not tell you whether you have cancer. Rather, it assesses a person’s risk of developing hereditary colorectal cancer and a woman’s risk of developing hereditary uterine (endometrial) cancer. COLARIS® detects mutations in the MLH1, MSH2, MSH6, PMS2, EPCAM and MYH genes. These are the gene mutations that are responsible for the vast majority of Lynch Syndrome and MYH-associated polyposis (MAP) cases. Only a small blood sample is taken for analysis.
How can COLARIS® testing benefit me?
Knowing if you have a gene mutation can help you know your risk of hereditary cancer and inform your family of their potential risk of hereditary cancer.
The COLARIS® test results may enable you and your family to make more informed choices and take proactive steps to be ready against hereditary cancer. They may also help your doctor to manage your healthcare needs more effectively.
Is COLARIS® testing suitable for me?
Myriad Genetics’ Hereditary Cancer Quiz helps you to assess whether you might be a good candidate for testing. This quiz can help you get the information you need to discuss your risk of cancer with your healthcare provider and ask for further evaluation. If you take the quiz and find red flags in your own history or your family history, you may benefit from hereditary cancer testing.
The quiz will help you determine if you are at risk for the following hereditary cancers:
- Breast Cancer
- Ovarian Cancer
- Colon Cancer
- Uterine Cancer
- Pancreatic Cancer
To begin the process of seeing if genetic testing is right for you, check out Myriad’s Hereditary Cancer Quiz: https://www.hereditarycancerquiz.com/
What is the unique advantage of Myriad COLARIS® testing?
No company has more experience in genetic testing for hereditary cancer than Myriad.
Over the last 20 years, Myriad has delivered more than one million test results.
Myriad has the lowest Variant of Uncertain Significance (VUS) rate globally with a <3% VUS rate (0.6% for BRCA1 mutations). A lower VUS rate means a lower chance of getting an uncertain result, which means more confidence and clarity in your results.
[accordion][accordion-item title="I already know I have a family history of cancer. Why should I get tested?"]Testing for a hereditary cancer risk helps you and your healthcare professional understand your risk so you can make the best choices for preventive care. Knowing your family history is an important first step, but testing can give you a more accurate picture of your risk. [/accordion-item][accordion-item title="I already have cancer. Why should I get tested?"]Testing for a hereditary cancer helps you and your healthcare professional understand your risk for developing a second primary cancer. This information can allow you to make the best choices for preventive care. [/accordion-item][accordion-item title="Is testing recommended for everyone?"]While testing is the most accurate way to determine the risk of hereditary cancer, only people who have cancer in their family or a personal history of the disease need to be tested. If you have had cancer and/or cancer runs in your family, let your healthcare professional know. To help you assess whether you may benefit from hereditary cancer genetic testing, take the Myriad Hereditary Cancer Quiz. This simple, 30-second quiz can help you get the information you need to discuss your risk of cancer with your healthcare professional and ask for further evaluation.[/accordion-item][accordion-item title="How do I get tested?"]Speak to your doctor. Once your doctor orders a test for you from us, we will take care of the rest. The clinic will take a small blood sample and send it to the lab for testing. The lab cannot accept a test directly from you, as a doctor first needs to assess whether or not the test is right for you. Once the testing is completed, a report will be sent to your doctor who will then go through and explain your results to you, and suggest the next steps.[/accordion-item][accordion-item title="Can I use any other sample collection kit that is not provided by Myriad?"]No! Our processes have been optimized and validated with the kits we provide. [/accordion-item][accordion-item title="Which completed forms must accompany my sample?"]The clinic will help you complete and sign an Informed Consent Form. This form will be submitted with the sample. The consent form will be used to match your sample to the test request submitted by the doctor, and is needed to let the lab know that you have agreed to send your sample for the test. Samples received without these forms cannot be processed, as your consent is required to test your sample.[/accordion-item][accordion-item title="Who will receive the test results?"]Myriad will provide your test report to the healthcare professional who ordered the test. [/accordion-item][accordion-item title="Why are the results of testing sent directly to the ordering healthcare professional rather than the patient or parent of a patient?"]Results are sent to the ordering healthcare professional as they would need to discuss the results, result interpretation, treatment management, and any follow-up testing with you.[/accordion-item][/accordion]