by Courtagen Life Sciences, Inc.
What are Neurodevelopmental Disorders?
Common neurodevelopmental disorders include developmental delay (DD), intellectual disability (ID), and autism spectrum disorders (ASD). These disorders are complex and have a wide range of symptoms and severity. Multiple lines of evidence support the strong role of genetics in these disorders.
What are the symptoms of Neurodevelop-mental Disorders (DD, ID, ASD)?
Developmental delay is typically used to describe children under the age of 6 years who have significant delay (as compared to age matched peers). Many of these children are later diagnosed with intellectual disability. Intellectual disability is characterized by an intelligence quotient (IQ) of 70 or below. Autism spectrum disorders are characterized by difficulties in social interaction, communication, and repetitive behaviors. The level of intellectual functioning is extremely variable in persons with ASD. It is estimated that around 50% of persons with ASD also suffer from an intellectual disability.
What is devSEEK™?
Courtagen’s devSEEK™ is a genetic test that identifies changes in a person’s DNA. The devSEEK™ analysis is performed from a saliva sample and tests for just over a hundred genes known to be associated with developmental delay, intellectual disability, and autism spectrum disorders.
How can devSEEK™ help me manage my child’s condition?
A positive or likely positive test result indicates that a genetic change is likely the cause of developmental delay, intellectual disability, and/or autism spectrum disorders. There are many reasons you might find it beneficial to have your child tested. A few include:
- A definitive diagnosis can facilitate acquisition of needed services and support. Early identification of developmental problems can lead to early and appropriate intervention.
- If a genetic cause is identified, it may lead to changes in his/her medical management.
- A genetic diagnosis eliminates unnecessary and/or prolonged diagnostic testing
- Knowledge of the underlying genetic cause of a disorder can empower families and aid in family planning
What is the unique advantage of devSEEK™ Clinical Management test from Courtagen?
Courtagen’s proprietary DREAM PCR process ensures superior lab decontamination and long sequencing reads result in exceptional coverage and sensitivity for the target genes in each panel. Courtagen’s high quality coverage exceeds that of shorter sequencing read tests and lower coverage whole exome sequencing (WES) approaches.
Courtagen’s Clinical Team has over 25 years of experience in treatment and genetic interpretation of neurological disorders, and results are delivered in a concise clinical report to help determine diagnosis and assist with decisions about treatment and disease management.
[accordion][accordion-item title="What is the process to submit a DNA sample for genetic testing?"]The process begins with your physician placing a test request. The lab will not accept a sample without a requisition from a licensed physician. Once a test requisition is received, a sample collection kit will be sent to your physician. The instructions for using our collection kit are here and are also included in every kit. The sample will be sent to the Courtagen Laboratory. Once testing is complete, Courtagen will provide a report to the ordering physician.[/accordion-item][accordion-item title="Can I use any other sample collection kit that is not provided by Courtagen?"]No! Our processes have been optimized and validated with the kits we provide.[/accordion-item][accordion-item title="If my physician ordered more than one test for me, do I have to provide a tube of saliva for each test?"]No. A single saliva collection will normally provide enough DNA to complete multiple tests. If we determine that we do not have enough DNA to perform the tests requested by your ordering physician, we will contact your physician to collect more sample.[/accordion-item][accordion-item title="Which completed forms must accompany my sample?"]The patient must submit a completely filled out and signed Informed Consent Form with their sample submission. The consent form will be used to match your sample to the ordering physician’s test requisition. Samples received without these forms cannot be processed.[/accordion-item][accordion-item title="Who will receive the test results?"]Courtagen will provide your test report to the physician or healthcare professional who ordered the test. [/accordion-item][accordion-item title="Why are the results of testing sent directly to the ordering physician rather than the patient or parent of a patient?"]Results are sent to the physician or healthcare professional to provide the physician with the opportunity to discuss the result interpretation and any follow-up testing with you.[/accordion-item][/accordion]