Hereditary Pancreatic Cancer

Approximately 46,000 new cases of pancreatic cancer are diagnosed in the U.S. each year, some of which are caused by a gene mutation that can be passed from generation to generation. Pancreatic cancer can be present in different hereditary cancer syndromes. Because of that, it is important to know your complete family history and evaluate which genetic syndrome is most likely. When pancreatic cancer is the predominant cancer in a family, the most common known causes are mutations in the PALB2, BRCA2 and p16 genes.

What is PANEXIA®?

PANEXIA® is a genetic test specifically created to detect mutations in genes that result in an increased risk of pancreatic cancer, offering insight about the risk of future hereditary cancers for patients and their families. PANEXIA®, via a simple blood test, analyzes the PALB2 and BRCA2 genes, the two genes most commonly identified in families with hereditary pancreatic cancer.

The PANEXIA® test results provide information for patients and their family members about the inherited risks of pancreatic cancer as well as breast, ovarian, and other cancers. This knowledge may allow at-risk family members the opportunity to lower their risks for some of these cancers through surveillance, preventative options, or lifestyle choices.

Is PANEXIA® suitable for me?

PANEXIA® is for individuals at risk for hereditary pancreatic cancer. If you and your doctor determine that you may be at risk for hereditary pancreatic cancer, PANEXIA® is right for you.

Because pancreatic cancer can be present in multiple hereditary cancer syndromes, it could also be useful to use a gene panel test such as Myriad myRisk™.

Genetic testing for hereditary pancreatic cancer with the Myriad myRisk™ Hereditary Cancer test should possibly be considered if:

  • You have or have had pancreatic cancer and have at least one close relative** with pancreatic cancer.
  • You have a personal or family history of pancreatic cancer and melanoma.
  • You have two or more close relatives** with pancreatic cancer.
  • You are of Ashkenazi Jewish descent and have a personal history of pancreatic cancer or a first-degree relative** with pancreatic cancer.
  • There is a previously identified PALB2, BRCA2 or p16 mutation in your family.

**Close refers to first- or second-degree relatives. First-degree relatives include parents, siblings, and children. Second-degree relatives include grandparents, aunts/uncles and nieces/nephews.

How can PANEXIA® help me manage my condition?

Knowing if you have a gene mutation can help you know your risk of hereditary cancer and inform your family of their potential risk of hereditary cancer.

The PANEXIA® test results may enable you and your family to make more informed choices and help you to be ready against hereditary cancer. They can also help your doctor manage your healthcare needs more effectively.


[accordion][accordion-item title=”How do I get tested?”]Speak to your doctor. Once your doctor orders a test for you from us, we will take care of the rest. The clinic will take a small blood sample and send it to the lab for testing. The lab cannot accept a test directly from you, as a doctor first needs to assess whether or not the test is right for you. Once the testing is completed, a report will be sent to your doctor who will then go through and explain your results to you, and suggest the next steps. [/accordion-item][accordion-item title=”Can I use any other sample collection kit that is not provided by Myriad?”]No! Our processes have been optimized and validated with the kits we provide. [/accordion-item][accordion-item title=”Which completed forms must accompany my sample?”]The clinic will help you complete and sign an Informed Consent Form. This form will be submitted with the sample. The consent form will be used to match your sample to the test request submitted by the doctor, and is needed to let the lab know that you have agreed to send your sample for the test. Samples received without these forms cannot be processed, as your consent is required to test your sample. [/accordion-item][accordion-item title=”Who will receive the test results?”]Myriad will provide your test report to the healthcare professional who ordered the test.[/accordion-item][accordion-item title=”Why are the results of testing sent directly to the ordering healthcare professional rather than the patient or parent of a patient?”]Results are sent to the ordering healthcare professional as they would need to discuss the results, result interpretation, treatment management, and any follow-up testing with you.[/accordion-item][/accordion]