by Ferrer inCode, S.L.
Cardiac Sudden Death
Sudden death is an unexpected natural death of cardiac origin occurring within one hour of the onset of the first symptoms. It is often wrongly confused with a myocardial infarction, but it does not have an ischemic origin and has a genetic origin.
Identifying Sudden Death Syndrome in Patients
Symptoms that indicate that a patient is suitable for a SudD inCode® test:
Family history of cardiac deaths at a young age, a patient who faints, an arrhythmia observed with electrocardiographic methods or a recovered cardiac arrest.
Some patients can show certain symptoms such as fainting and arrhythmia, but in many cases a cardiac arrest takes place. The SudD inCode® test is designed to find the disease-causing mutations in these individuals and the mutations are then screened in family members to identify asymptomatic individuals who can develop the disease in the future. The right diagnosis saves lives through measures such as the implantation of a defibrillator.
The SudD inCode® service analyzes this genetic information together with the patient’s clinical data to enable healthcare professionals to:
- Identify the causal mutation in the index case and in first-degree relatives.
- Establish clinical diagnosis
- Confirm clinical diagnosis
- Provide recommendations for the optimum management of patients
Recommendations are supported by an international team of experts in cardiac sudden death that help healthcare professionals provide the best clinical and genetic assessment of patients.
This service is also available for the relatives of a diagnosed index case.
- Patients who suffer unexplained syncope, idiopathic ventricular fibrillation, heart arrest and/ortorsades de points induced by drugs.
- Cases of sudden death of unknown origin or with doubtful electrocardiographic signs and suspicion of hereditary sudden death.
Patients with underlying arrhythmogenic heart disease:
- Long QT Syndrome (LQTS)
- Brugada Syndrome (BrS)
- Short QT Syndrome (SQTS)
- Sick sinus Syndrome (SSS)
- Unexplained Bradycardia
- Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT)
- Arrhythmia during exercise
- Progressive Conduction Defect
Patients with underlying structural heart disease:
- Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC)
- Hypertrophic Cardiomiopathy (HCM)
- Unexplained cardiac hypertrophy (UCH)
- Dilated Cardiomiopathy (HCM)
- Non Compaction Cardiomiopathy (adult and neonatal)
- Restrictive Cardiomiopathy
Patients with other associated syndromes:
- Marfan Syndrome (MS)
- Fabry’s Disease (FD)
- Thoracic aortic aneurysms and aortic dissections (TAAD)
- Glycogen deposit disease (GDD)
- Wolff-Parkinson White Syndrome
Medical Management of Patients with Cardiac Sudden Death Syndrome
By integrating clinical and genetic data of patients, the cardiologist can use different therapeutic measures, from pharmaceuticals to catheter ablation or the implantation of a defibrillator and follow asymptomatic individuals who could not be identified as mutation carriers through conventional methods.
Benefits of SudD inCode® Testing
The SudD inCode® is based on Next Generation Sequencing (NGS) methods and has the capability to identify a single causing mutation in a panel of up to 55 validated genes. Regardless the ethnicity of the patient, rare mutations are found through this method.
What is the unique advantage of the SudD inCode® test from Ferrer inCode?
The quality reached through the NGS method plus the delivered clinical and genetic report written by the Burgada brothers, three of the top world-wide experts in the field, offer a more valuable solution than genetic testing labs not specialized in cardiology.
SudD inCode® FAQs
[accordion][accordion-item title="How do I order a test?"]Please contact us and let us know if you would like to order a test for a patient. One of our representatives will get in touch with you and advise on the workflow, and provide the necessary forms and sample collection kits. Once the samples have been collected, we will coordinate the shipment of the sample to the laboratory. Once testing is completed, the report will be sent to you.[/accordion-item][accordion-item title="How is SudD inCode® Performed?"]It is performed from a saliva sample or blood from the index case, the person in the family who showed sudden death symptoms. Once mutations are identified, they can be tested in the family members. [/accordion-item] [accordion-item title="How long does it take for SudD inCode® results?"]The index case takes around 10–12 weeks, and family mutation screening takes around 2 weeks.[/accordion-item] [/accordion] [accordion] [accordion-item title="What does a SudD inCode® result reveal to a patient?"] The genetic mutation substrate causing the disease and the treatment recommendations based also on the patient clinical data reduce uncertainty to the cardiologist. [/accordion-item] [/accordion] [accordion] [accordion-item title="What symptoms indicate that a patient is suitable for a SudD inCode® test?"] Family history of cardiac deaths at a young age, a patient who faints, an arrhythmia observed with electrocardiographic methods or a recovered cardiac arrest. [/accordion-item] [/accordion]