What is Functional Disorder?

A functional disorder is a medical condition that impairs the normal function of a bodily process, but where the body or associated organs appear normal under examination, imaging, laboratory values, or other standard studies. Multiple functional symptoms in one individual suggests a genetic condition as the underlying cause.

What are the symptoms of Functional Disorder?

Functional disorders can present with diverse symptoms that may occur in multiple systems. Some examples of indications for testing are: chronic pain conditions (joint, bone, myalgia), autonomic dysfunction (dizziness, POTS, arrhythmias), gastrointestinal conditions (dysmotility, intermittent diarrhea or constipation, abdominal pain, recurrent vomiting, nausea, GERD), psychiatric / mood disorders (depression, anxiety, schizophrenia), abnormal movement (tics, tremor, dyskinesia, restless legs), migraine headache, fatigue/exercise intolerance, autistic spectrum disorder with additional functional symptoms, ADHD and other behavioural conditions, neuropathy/sensory deficits, sleep disturbance.


What is theraSEEK™?

The theraSEEK™ panel looks for genetic variations within a selection of genes primarily associated with functional symptoms.

The panel includes 299 genes, encompassing:
• Metabolism and physiological functions (amino acids, carbohydrates/glucose, cell signaling, cofactors, metals, select drugs, extracellular matrix, fatty acid oxidation, glycosylation, heme, ion channels, lipids, lysosomes, neurotransmitters, organic acids, peroxisomes, purines/pyrimidines, transcription/translation, urea cycle);
• Metabolic pathways (antioxidant, biopterin, coenzyme Q10, folate, methionine, transsulfuration);
• Neurological development and function;
• Mitochondrial function (electron transport chain, mtDNA replication, morphology).

In addition to full sequencing for rare genetic disease-causing variants, the test includes a SNP analysis for common variants associated with biochemical pathways. Physicians will receive the genetic analysis report, plus a separate SNP analysis report with 60 SNPs, and a data file with over 1,100 SNPs.

How can theraSEEK™ help me manage my child’s condition?

Genetic testing is a valuable tool for obtaining a definitive diagnosis in the patient, thereby providing insight to the prognosis, treatment choices, and recurrence risks for the family. Importantly, understanding the genetic basis of the patient’s condition can assist your doctor in developing a targeted personalized treatment plan, which may include medication, nutritional interventions, supplements, other therapies, or avoidance of certain agents.

What is the unique advantage of the theraSEEK™ test from Courtagen?

Courtagen’s proprietary DREAM PCR process ensures superior lab decontamination and long sequencing reads result in exceptional coverage and sensitivity for the target genes in each panel. Courtagen’s high quality coverage exceeds that of shorter sequencing read tests and lower coverage whole exome sequencing (WES) approaches. Courtagen’s Clinical Team has over 25 years of experience in treatment and genetic interpretation of neurological disorders, and results are delivered in a concise clinical report to help determine diagnosis and assist with decisions about treatment and disease management.


[accordion] [accordion-item title=”What is the process to submit a DNA sample for genetic testing?”]The process begins with your physician placing a test request. The lab will not accept a sample without a requisition from a licensed physician. Once a test requisition is received, a sample collection kit will be sent to your physician. The instructions for using our collection kit are here and are also included in every kit. The sample will be sent to the Courtagen Laboratory. Once testing is complete, Courtagen will provide a report to the ordering physician.[/accordion-item][accordion-item title=”Can I use any other sample collection kit that is not provided by Courtagen?”]No! Our processes have been optimized and validated with the kits we provide.[/accordion-item][accordion-item title=”If my physician ordered more than one test for me, do I have to provide a tube of saliva for each test?”]No. A single saliva collection will normally provide enough DNA to complete multiple tests. If we determine that we do not have enough DNA to perform the tests requested by your ordering physician, we will contact your physician to collect more sample.[/accordion-item] [accordion-item title=”Which completed forms must accompany my sample?”]The patient must submit a completely filled out and signed Informed Consent Form with their sample submission. The consent form will be used to match your sample to the ordering physician’s test requisition. Samples received without these forms cannot be processed.[/accordion-item] [accordion-item title=”Who will receive the test results?”]Courtagen will provide your test report to the physician or healthcare professional who ordered the test.[/accordion-item] [accordion-item title=”Why are the results of testing sent directly to the ordering physician rather than the patient or parent of a patient?”]Results are sent to the physician or healthcare professional to provide the physician with the opportunity to discuss the result interpretation and any follow-up testing with you.[/accordion-item][/accordion]