Intestinal Inflammation
TECHLAB manufactures several diagnostics that detect lactoferrin and other markers of inflammation in the bowels
Rapid Test
The LACTOFERRIN EZ VUE® is an immunochromatographic test for the qualitative detection of elevated levels of lactoferrin, a marker for fecal leukocytes and an indicator of intestinal inflammation. The test can be used as an in vitro diagnostic aid to identify patients with an active inflammatory bowel disease (IBD) and rule out those with active noninflammatory irritable bowel syndrome (IBS).
IBD, which is a condition of chronic inflammation, consists of ulcerative colitis and Crohn’s disease. Both of these diseases result in elevated fecal lactoferrin. As a result, patients with these diseases test positive in the LACTOFERRIN EZ VUE® test.
In patients with active IBS, the intestine appears normal upon endoscopic examination and there is no indication of inflammation. As a result, IBS patients test negative in the LACTOFERRIN EZ VUE® test.
- Simple-to-use lateral flow format
- Rapid screen to determine presence of intestinal inflammation
- Accurate measurement of both solid and liquid fecal samples using novel pipet design
- Noninvasive
Results indicators
- Proper test performance is indicated by the formation of a red line at the control side (C) of the Results Window.
- A positive result is indicated by the formation of a red line at the test side (T) of the Results Window.
Documentation
- Package Insert (PDF) U.S. only, Issued 07/16
- CPT Codes (PDF) Issued 08/2018
The LEUKO EZ VUE® is an immunochromatographic test for the qualitative detection of elevated levels of fecal lactoferrin, a marker for fecal leukocytes and an indicator of intestinal inflammation. The LEUKO EZ VUE® test detects lactoferrin in liquid, semi-liquid, and solid fecal specimens. A positive test result indicates an increased level of fecal lactoferrin and warrants additional testing.
Diarrheal diseases can be classified into inflammatory and noninflammatory diarrhea. Non-inflammatory diarrheas include those caused by viruses and most parasites and are, for the most part, effectively treated with simple oral rehydration therapy. Inflammatory diarrheas, on the other hand, tend to be more serious and need to be followed up by more extensive testing. The LEUKO EZ VUE® overcomes the problems of microscopy by utilizing immunochromatography technology and provides results in 10 minutes. The assay detects elevated lactoferrin in fecal specimens. Lactoferrin is very stable and is not degraded during infections.
*T30355 is the new global catalog number for this product. This catalog number supersedes both catalog #T5019 and catalog #30355.
- Rapid screen to determine presence of intestinal inflammation in acute intestinal illnesses
- Accurate measurement of both solid and liquid fecal samples using novel pipet design
- Simple procedure that includes visual readings
Results indicators
- Proper test performance is indicated by the formation of a red line at the control side (C) of the Results Window.
- A positive result is indicated by the formation of a red line at the test side (T) of the Results Window.
Documentation
- Package Insert (PDF) Issued 07/16
- CPT Codes (PDF) Issued 08/2018
LEUKO EZ VUE® Publications
A New Test for the Detection of White Blood Cells in Stool Samples, excerpted with permission from the MSCLS Newslinks newsletter Volume 21, Issue 6
Microassay Plates
A quantitative ELISA for the detection of fecal lactoferrin.The LACTOFERRIN SCAN® test is a quantitative ELISA for measuring concentrations of fecal lactoferrin, a marker of fecal leukocytes. An elevated level is an indicator of intestinal inflammation.The test can be used as an in vitro diagnostic aid to distinguish patients with active inflammatory bowel disease (IBD) from those with noninflammatory irritable bowel syndrome (IBS). In addition, the test can be used to assess when an IBD patient is in confirmed remission and has responded to treatment.
- Quantitative assay to determine the concentration of fecal lactoferrin present to guide treatment decisions
- Prediluted standards
- Accurate measurement of both solid and liquid fecal samples using novel pipet design
- Noninvasive
- Automatable
Documentation
- Package Insert (PDF) Issued 11/2017
- CPT Codes (PDF) Issued 08/2018
LACTOFERRIN SCAN® Publications and Poster Presentations
- Ribotype 027 is Associated with Increased Lactoferrin and Toxin in Patients with Clinically Defined C. difficile Disease
American Society of Microbiology meeting, May 2011, New Orleans, LA - Evaluation of Fecal Lactoferrin, CRP and Clinical Activity Indices for Assessing the Presence of Intestinal Inflammation in IBD and IBS Patients Classified by Ileocolonoscopy
- Comparison of CRP, Clinical Activity Indices and Fecal Lactoferrin with Disease Status in Ileocolonoscopy of Patients with IBD and IBS
Digestive Disease Week, May 2006, Los Angeles, CA - A Comparison Among Four Neutrophil-Derived Proteins in Feces as Indicator of Disease Activity in Ulcerative Colitis
Digestive Disease Week, May 2004, New Orleans, LA - Serial Fecal Lactoferrin Measurements are Useful in the Interval Assessment of Patients with Active and Inactive Inflammatory Bowel Disease
Digestive Disease Week, May 2004, New Orleans, LA - Fecal Lactoferrin: Sensitive Marker for Monitoring Pediatric Patients with Inflammatory Bowel Disease (IBD)
Digestive Disease Week, May 2003, Orlando, FL
The LACTOFERRIN CHEK® is an ELISA for the qualitative detection of elevated levels of lactoferrin, a marker for fecal leukocytes and an indicator of intestinal inflammation. The test can be used as an in vitro diagnostic aid to identify patients with active inflammatory bowel disease (IBD) and rule out those with active irritable bowel syndrome (IBS), which is noninflammatory.IBD, which is a condition of chronic inflammation, consists of ulcerative colitis and Crohn’s disease. Both of these diseases result in elevated fecal lactoferrin. As a result, patients with these diseases test positive in the LACTOFERRIN CHEK® test.In patients with active IBS, the intestine appears normal upon endoscopic examination and there is no indication of inflammation. As a result, IBS patients test negative in the LACTOFERRIN CHEK® test.
- Simple-to-use microwell format
- Rapid screen to determine presence of intestinal inflammation
- Accurate measurement of both solid and liquid fecal samples using novel pipet design
Documentation
- Package Insert (PDF) Issued 01/2021
- CPT Codes (PDF) Issued 08/2018
LACTOFERRIN CHEK® Poster Presentations and Publications
- Clinical Evaluation of the IBD-CHEK® Test for Detecting Elevated Fecal Lactoferrin as an Indicator of Intestinal Inflammation in Pediatric Patients
Digestive Disease Week, May 2003, Orlando, FL
The ASCA-CHEK™ test is an ELISA for the qualitative detection of human anti-S. cerevisiae antibodies (ASCA) in feces and serum. The test result is used as an aid in the diagnosis of Crohn’s disease in combination with clinical and laboratory findings.The ASCA-CHEK™ test is an enzyme-linked immunoassay (EIA) for detecting ASCA in human feces and serum. The test provides a method utilizing antigens of Saccharomyces cerevisiae for measuring total fecal and serum ASCA as an aid to distinguish Crohn’s disease from other gastrointestinal illnesses such as ulcerative colitis and irritable bowel syndrome.
Novel pipet design for accurate measurement of both solid and liquid fecal samples
Documentation
- Package Insert (PDF) Issued 10/18
- CPT Codes (PDF) Issued 08/2018
ASCA-CHEK™ Poster Presentations
Related Products
For more details on Lactoferrin Diagnostics, please click here.
LACTOFERRIN SCAN®
LACTOFERRIN CHEK®
LACTOFERRIN EZ VUE®
| Intestinal Inflammation | Catalog # | Suggested CPT Code | Tests/Kit | Analyte(s) Detected | Format | Time to Result | Fecal Sample Type |
|---|---|---|---|---|---|---|---|
| LACTOFERRIN SCAN® | T5009/30351 | 83631 | 96 | Lactoferrin-marker for fecal leukocytes & indicator for intestinal inflammation; aids in the diagnosis of IBD/IBS populations | Microplate ELISA Quantitative | ~75min | Fresh samples (undiluted, unpreserved) stored between 20C - 80C or room temperature for up to 2 weeks, then stored frozen. |
| LACTOFERRIN CHEK® | T5008/30352 | 83630 | 96 | Lactoferrin-marker for fecal leukocytes & indicator for intestinal inflammation; aids in the diagnosis of IBD/IBS populations | Microplate ELISA Qualitative | ~75min | Fresh samples (undiluted, unpreserved) stored between 20C - 80C or room temperature for up to 2 weeks, then stored frozen. |
| LACTOFERRIN EZ VUE® | T5018/30353 | 83630 | 25 | Lactoferrin-marker for fecal leukocytes & indicator for intestinal inflammation; aids in the diagnosis of IBD/IBS populations | Lateral Flow Qualitative | 10min | Fresh samples (undiluted, unpreserved) stored between 20C - 80C or room temperature for up to 2 weeks, then stored frozen. |
| ASCA-CHEKTM | T5016 | 83520 | 96 | Detects anti-S, cerevisiae antibodies; aids in the diagnosis of Crohn's disease | Microplate ELISA Qualitative | ~75min | Fresh & frozen fecal sample (unpreserved; fecal specimens should be frozen if not tested within 48 hours) / Serum (freeze if not tested within 7 days) |
