A recently published report details the experience of Indiana University School of Medicine, who recently made a change from PCR-only to a two-step algorithm C. diff testing. The change in testing algorithm correlated with a significant decrease in C. difficile-specific antibiotic treatment.

"Likely colonized" patients were 20X less likely to receive antibiotics following the testing change, with no negative impact to patient outcomes observed.

1. Dbeibo L, Lucky CW, Fadel WF, Sadowski J, Beeler C, Kelley K, Williams J, Webb D, Kara A. Two-step algorithm-based Clostridioides difficile testing as a tool for antibiotic stewardship. Clin Microbiol Infect. 2023 Jun;29(6):798.e1-798.e4. doi: 10.1016/j.cmi.2023.02.008

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